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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challengeThis review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiologycancer.Additionally, we highlight the development and application of multi-omics approaches in pancreatic cancerresearch and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy.

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy    

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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 387-411 doi: 10.1007/s11684-018-0646-8

Abstract: evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancerin relation to crosstalk with some other signaling pathways, and the roles of TGF-β in lung and pancreaticcancers, in which TGF-β has been shown to be involved in cancer progression.

Keywords： TGF-β     EMT     lung cancer     pancreatic cancer     latent form     immune function     GARP    

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Laparoscopic surgery for pancreatic lesions: current status and future

Taiping Zhang, Xiao Du, Yupei Zhao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 277-282 doi: 10.1007/s11684-011-0147-5

Abstract: Laparoscopic pancreatic surgery has been gaining increasing recognition in recent years, and its practiceProspective, randomized, controlled trials of laparoscopic operation versus open pancreatic surgery arenecessary to justify the wide application and routine practice of the laparoscopic procedure for pancreatic

Keywords： minimally invasive surgery     pancreatic surgery     pancreatic neoplasm     distal pancreatic lesions     pancreatic    

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Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status

Li Jiang, Deng Ning, Xiaoping Chen

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 251-261 doi: 10.1007/s11684-019-0727-3

Abstract: Postoperative pancreatic fistula (POPF) is the most common and critical complication after pancreaticHow to effectively reduce the occurrence of pancreatic fistula and conduct timely treatment thereafterRecent research standardized the definition of pancreatic fistula and stressed the correlation betweenAccording to the literature, identification of the risk factors for pancreatic fistula contributed toAppropriate management of the pancreatic stump and perioperative treatment are of great significance

Keywords： pancreatic fistula     pancreatic body and tail resection     distal pancreatectomy    

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The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: a meta-analysis

Xiangsong Wu, Maolan Li, Wenguang Wu, Jiasheng Mu, Lin Zhang, Qichen Ding, Qian Ding, Hao Weng, Runfa Bao, Yijun Shu, Ping Dong, Jun Gu, Jianhua Lu, Yingbin Liu

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 499-505 doi: 10.1007/s11684-013-0296-9

Abstract:

Pancreatic fistula (PF) is the most frequent complication after distal pancreatectomy (DP).Prophylactic transpapillary pancreatic stenting (PTPS) has been proposed recently for the prevention

Keywords： pancreatic fistula     distal pancreatectomy     pancreatic stent     meta-analysis    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 430-435 doi: 10.1007/s11684-010-0700-7

Abstract: This study aimed to investigate the effect of adjuvant therapy on the treatment of stage II pancreaticThe clinical data of 139 cases of stage II pancreatic carcinoma were analyzed retrospectively.be suggested according to the general condition of the patients after radical resection for stage II pancreatic

Keywords： pancreatic neoplasms     neoadjuvant therapy     survival    

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Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological

Yugang Cheng,Hanxiang Zhan,Lei Wang,Jianwei Xu,Guangyong Zhang,Zongli Zhang,Sanyuan Hu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 444-450 doi: 10.1007/s11684-016-0471-x

Abstract:

The incidence rate of pancreatic neuroendocrine neoplasms (pNENs) has increased rapidly in recent

Keywords： pancreatic neuroendocrine neoplasms     clinicopathological characteristic     Ki-67     liver metastasis     outcomes    

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Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects

Yongjun Chen, Renyi Qin, Xiaoping Chen

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 235-238 doi: 10.1007/s11684-011-0156-4

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Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: The dendritic cell vaccine is a treatment vaccine with potent clinical applications. Functional cytokines can enhance dendritic cell anti-tumor immune responses. This experiment was conducted to study the effects of bone marrow-deriv

Keywords： Functional     experiment     anti-tumor     dendritic     clinical    

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Total pancreatic necrosis after organophosphate intoxication

Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 285-288 doi: 10.1007/s11684-018-0626-z

Abstract: occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreaticShe received percutaneous catheterization and drainage of pancreatic zone to expel hazardous necroticpancreatin capsules before meals and hypodermic insulin at meals and bedtime to compensate the impaired pancreatic

Keywords： organophosphate intoxication     severe acute pancreatitis     pancreas necrosis     percutaneous catheterization     sandostatin     insulin    

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Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 91-100 doi: 10.1007/s11684-019-0696-6

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the ninth most common human malignancy and the sixth leadingcause of cancer-related death in China.HOXB9 post-transcriptional modification that can predict the outcome in lung adenocarcinoma and colon cancerTissue microarrays consisting of 162 pancreatic tumor tissue samples from patients with PDAC and paired

Keywords： HOXB9     AcK27-HOXB9     PDAC    

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Effect of end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture in pancreatic

ZHANG Xuewen, XUAN Wei, JIANG Tao, JI Degang, YANG Yongsheng, ZHANG Dan, XIE Yingjun, MENG Zihui, ZHAO Jisheng

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 46-48 doi: 10.1007/s11684-007-0009-3

Abstract: The aim of this paper is to summarize the methods of pancreaticojejunostomy in the pancreatic operationThe incidences of pancreatic fistula with different types of pancreaticojejunostomy were compared.The overall incidence rate of pancreatic fistula was 26.5% (22/83).No pancreatic fistula occurred in end-to-end invagination pancreaticojejunostomy with circle discontinuousinvagination pancreaticojejunostomy with circle discontinuous U suture has a definite effect on avoiding pancreatic
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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Title Author Date Type Operation

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Journal Article

Laparoscopic surgery for pancreatic lesions: current status and future

Taiping Zhang, Xiao Du, Yupei Zhao

Journal Article

Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status

Li Jiang, Deng Ning, Xiaoping Chen

Journal Article

The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: a meta-analysis

Xiangsong Wu, Maolan Li, Wenguang Wu, Jiasheng Mu, Lin Zhang, Qichen Ding, Qian Ding, Hao Weng, Runfa Bao, Yijun Shu, Ping Dong, Jun Gu, Jianhua Lu, Yingbin Liu

Journal Article

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Journal Article

Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological

Yugang Cheng,Hanxiang Zhan,Lei Wang,Jianwei Xu,Guangyong Zhang,Zongli Zhang,Sanyuan Hu

Journal Article

Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects

Yongjun Chen, Renyi Qin, Xiaoping Chen

Journal Article

Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

Total pancreatic necrosis after organophosphate intoxication

Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu

Journal Article

Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal

Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang

Journal Article

Effect of end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture in pancreatic

ZHANG Xuewen, XUAN Wei, JIANG Tao, JI Degang, YANG Yongsheng, ZHANG Dan, XIE Yingjun, MENG Zihui, ZHAO Jisheng

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article